Catalytic antibodies for the hydrolysis of unactivated peptides.
نویسندگان
چکیده
I102 does C5, and with slightly greater efficiency. Kinetic properties for these reactions have not been determined yet, but the rate enhancements above background are not as large as for the original substrate 7. The presence of the amino group opens additional mechanisms for the reaction of 8 and 9 in which the amino group acts as a nucleophile or as a general base. The latter mechanism would parallel that demonstrated for C3 with substrate 7, with a neutral general base acting in place of a presumed anionic base.
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عنوان ژورنال:
- Biochemical Society transactions
دوره 21 4 شماره
صفحات -
تاریخ انتشار 1993